Yintoni iNitric oxide?
I-nitric oxide yigesi eveliswa ziiseli ezibandakanyekayo ekudumbeni okunxulumene ne-asthma okanye i-eosinophilic asthma.
Yintoni iFeNO?
Uvavanyo lwe-Fractional exhaled Nitric Oxide (FeNO) yindlela yokulinganisa ubuninzi be-nitric oxide kumoya ophumayo.Olu vavanyo lunokunceda ukuxilongwa kwe-asthma ngokubonisa inqanaba lokudumba kwimiphunga.
Uncedo lweKlinikhi yeFeNO
I-FeNO inokubonelela nge-adjunct engabonakaliyo yokuxilongwa kokuqala kwe-asthma kunye ne-ATS kunye ne-NICE incoma njengenxalenye yezikhokelo zabo zangoku kunye ne-diagnostic algorithms.
| Abantu abadala | Abantwana | |
| I-ATS (2011) | Phezulu: > 50 ppb Phakathi: 25-50 ppb Phantsi:<25 ppb | Phezulu: > 35 ppb Phakathi: 20-35 ppb Phantsi:<20 ppb |
| I-GINA (2021) | ≥ 20 ppb | |
| OKUHLE (2017) | ≥ 40 ppb | > 35 iippb |
| Imvumelwano yaseScottish (2019) | >40 ppb ICS-izigulane ezingenangqondo > Izigulana ezingama-25 ze-ppb ezithatha i-ICS |
Izifinyezo: I-ATS, i-American Thoracic Society;I-FeNO, i-fractional ex- haled nitric oxide;I-GINA, iNyathelo leHlabathi leMbefu;I-ICS, i-corticosteroid ephefumlelweyo;I-NICE, iZiko leSizwe lezeMpilo kunye neNkathalo eGqwesileyo.
Izikhokelo ze-ATS zichaza amanqanaba aphezulu, aphakathi, naphantsi e-FeNO kubantu abadala njenge> 50 ppb, 25 ukuya kwi-50 ppb, kunye <25 ppb, ngokulandelanayo.Ngelixa kubantwana, amanqanaba aphezulu, aphakathi, naphantsi e-FeNO achazwa njenge> 35 ppb, 20 ukuya kwi-35 ppb, kunye <20 ppb (Itheyibhile 1).I-ATS incoma ukusetyenziswa kwe-FeNO ukuxhasa ukuxilongwa kwe-asthma apho ubungqina obunenjongo bufunekayo, ngokukodwa ekuxilongweni kwe-eosinophilic inflammation.I-ATS ichaza ukuba amanqanaba aphezulu e-FeNO (> 50 ppb kubantu abadala kunye> 35 ppb kubantwana), xa ichazwa kwimeko yeklinikhi, ibonisa ukuba ukuvuvukala kwe-eosinophilic kukho ukusabela kwe-corticosteroid kwizigulane ezinempawu, ngelixa amanqanaba aphantsi (<25 ppb kubantu abadala kunye <20 ppb ebantwaneni) yenza oku kungenzeki kwaye amanqanaba aphakathi kufuneka atolikwe ngononophelo.
Izikhokelo zangoku ze-NICE, ezisebenzisa amanqanaba aphantsi okunqunyulwa kwe-FeNO kune-ATS (Itheyibhile 1), incoma ukusetyenziswa kwe-FeNO njengenxalenye yomsebenzi wokuxilonga apho ukuxilongwa kwe-asthma kuthathwa khona kubantu abadala okanye apho kukho ukungaqiniseki kokuxilongwa kubantwana.Amanqanaba e-FeNO aphinda atolikwa kwimeko yeklinikhi kunye novavanyo olongezelelweyo, olufana novavanyo lwe-bronchial provocation lunokunceda ukuxilongwa ngokubonisa i-airway hyperresponsiveness.Izikhokelo ze-GINA zivuma indima ye-FeNO ekuchongeni ukuvuvukala kwe-eosinophilic kwi-asthma kodwa okwangoku ayiboni indima ye-FeNO kwi-algorithms yokuxilongwa kwe-asthma.I-Scottish Consensus ichaza i-cut-offs ngokwe-steroid exposure kunye nemilinganiselo emihle ye> 40 ppb kwizigulane ze-steroid-naive kunye>>25 ppb kwizigulane kwi-ICS.
Ixesha lokuposa: Mar-31-2022